human MYBPC1 shRNA silencing AAV

Name
AAV-h-MYBPC1-shRNA

Cat No
shAAV-216128

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MYBPC1.

shAAV-216128

AAV-h-MYBPC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MYBPC1 (myosin binding protein C, slow type). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LCCS4; MYBPCC; MYBPCS

Description (Vector)

MYBPC1 encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

4604

Gene Name (Vector)

myosin binding protein C, slow type

Gene Symbol

MYBPC1

HGNC ID

HGNC:7549

ORF Size (aa)

3372

ORF Size (bp)

3372 bp

RefSeq ID

NM_002465

RefSeq Synonyms

NM_206821, NM_206820, NM_206819, NM_002465, NM_001254723, NM_001254722, NM_001254721, NM_001254720, NM_001254719, NM_001254718, BC143504, BC143503, BC143502, BC143495, BC117217, BC092418,

Species

human

UniGene ID

Hs.654589

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.