human MTMR3 shRNA silencing AAV

Name 
AAV-h-MTMR3-shRNA
Cat No 
shAAV-216019
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MTMR3.

shAAV-216019
AAV-h-MTMR3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MTMR3 (myotubularin related protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FYVE-DSP1; ZFYVE10
Description (Vector)
MTMR3 encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
8897
Gene Name (Vector)
myotubularin related protein 3
Gene Symbol
MTMR3
HGNC ID
HGNC:7451
ORF Size (aa)
3597
ORF Size (bp)
3597 bp
RefSeq ID
NM_021090
RefSeq Synonyms
NM_153051, NM_153050, NM_021090, BC152455, BC151217, BC148216, BC142713, BC141656, BC141654,
Species
human
UniGene ID
Hs.474536

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.