human MTHFS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MTHFS.
shAAV-215997
AAV-h-MTHFS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MTHFS (5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HsT19268
Description (Vector)
MTHFS is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
10588
Gene Name (Vector)
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Gene Symbol
MTHFS
HGNC ID
HGNC:7437
ORF Size (aa)
612
RefSeq ID
NM_006441
RefSeq Synonyms
NM_006441, NM_001199758, BC019921,
Species
human
UniGene ID
Hs.459049
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.