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human MRPS15 shRNA silencing AAV

Name 
AAV-h-MRPS15-shRNA
Cat No 
shAAV-215849
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MRPS15.

shAAV-215849
AAV-h-MRPS15-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MRPS15 (mitochondrial ribosomal protein S15). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
28S ribosomal protein S15, mitochondrial; DC37; mitochondrial small ribosomal subunit protein uS15m; MPR-S15; MRP-S15; RPMS15; S15mt
Description (eCommerce)
The gene MRPS15 encodes for 28S ribosomal protein S15, mitochondrial, a subunit protein that belongs to the ribosomal protein S15P family. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins [taken from NCBI Entrez Gene (Gene ID: 64960)].
Description (Vector)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q.
Gene ID
64960
Gene Name (eCommerce)
mitochondrial ribosomal protein S15
Gene Name (Vector)
mitochondrial ribosomal protein S15
Gene Symbol
MRPS15
HGNC ID
HGNC:14504
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
774
Protein Name (eCommerce)
28S ribosomal protein S15, mitochondrial
RefSeq ID
NM_031280
RefSeq Synonyms
NM_031280, BC031336,
Research Areas
Mitochondrion,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
The gene MRPS15 encodes for 28S ribosomal protein S15, mitochondrial, a subunit protein that belongs to the ribosomal protein S15P family. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins [taken from NCBI Entrez Gene (Gene ID: 64960)].
UniGene ID
Hs.352839
UniProt ID (eCommerce)
P82914

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.