human MPZL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MPZL2.
shAAV-215739
AAV-h-MPZL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MPZL2 (myelin protein zero like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EVA; EVA1
Description (Vector)
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.
Gene ID
10205
Gene Name (Vector)
myelin protein zero like 2
Gene Symbol
MPZL2
HGNC ID
HGNC:3496
ORF Size (aa)
648
RefSeq ID
NM_005797
RefSeq Synonyms
NM_144765, NM_005797, BC017774,
Species
human
UniGene ID
Hs.116651
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.