human MMP25 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MMP25.
shAAV-215591
AAV-h-MMP25-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MMP25 (matrix metallopeptidase 25). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Gene ID
64386
Gene Name (Vector)
matrix metallopeptidase 25
Gene Symbol
MMP25
HGNC ID
HGNC:14246
ORF Size (aa)
1689
ORF Size (bp)
1689 bp
RefSeq ID
NM_022468
RefSeq Synonyms
NM_022468, BC167800,
Species
human
UniGene ID
Hs.654979
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.