human MMP20 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MMP20.
shAAV-215586
AAV-h-MMP20-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MMP20 (matrix metallopeptidase 20). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI2A2; MMP-20
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.
Gene ID
9313
Gene Name (Vector)
matrix metallopeptidase 20
Gene Symbol
MMP20
HGNC ID
HGNC:7167
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
RefSeq ID
NM_004771
RefSeq Synonyms
NM_004771, BC152741,
Species
human
UniGene ID
Hs.591946
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.