human MMP17 shRNA silencing AAV

Name
AAV-h-MMP17-shRNA

Cat No
shAAV-215582

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MMP17.

shAAV-215582

AAV-h-MMP17-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MMP17 (matrix metallopeptidase 17). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MMP-17; MT4-MMP; MT4MMP; MTMMP4

Description (Vector)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Gene ID

4326

Gene Name (Vector)

matrix metallopeptidase 17

Gene Symbol

MMP17

HGNC ID

HGNC:7163

ORF Size (aa)

1821

ORF Size (bp)

1821 bp

RefSeq ID

NM_016155

RefSeq Synonyms

NM_016155, BC045610, BC040507,

Species

human

UniGene ID

Hs.709245

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.