human MMAB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MMAB.
shAAV-215549
AAV-h-MMAB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MMAB (methylmalonic aciduria (cobalamin deficiency) cblB type). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATR; cblB; CFAP23; cob
Description (Vector)
MMAB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found.
Gene ID
326625
Gene Name (Vector)
methylmalonic aciduria (cobalamin deficiency) cblB type
Gene Symbol
MMAB
HGNC ID
HGNC:19331
ORF Size (aa)
753
RefSeq ID
NM_052845
RefSeq Synonyms
NM_052845, BC011831, BC005054,
Species
human
UniGene ID
Hs.12106
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.