human MLLT3 shRNA silencing AAV

Name
AAV-h-MLLT3-shRNA

Cat No
shAAV-215533

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MLLT3.

shAAV-215533

AAV-h-MLLT3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MLLT3 (MLLT3, super elongation complex subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AF9; ALL1-fused gene from chromosome 9 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; myeloid/lymphoid or mixed-lineage leukemia; translocated to 3; protein AF-9; YEATS domain-containing protein 3; YEATS3

Description (eCommerce)

The human AF9 gene is one of the most common fusion partner genes with the MLL (mixed lineage leukemia) gene resulting in AF9/MLL translocations and leukemogenesis. AF9 is highly homologous to the gene product of ENL, another common MLL fusion partner gene. The function of AF9 is not known but through studies of ENL it is proposed to be a nuclear transactivating factor.

Gene ID

4300

Gene Name (eCommerce)

MLLT3, super elongation complex subunit

Gene Name (Vector)

MLLT3, super elongation complex subunit

Gene Symbol

MLLT3

HGNC ID

HGNC:7136

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1707

ORF Size (bp)

1707 bp

Protein Name (eCommerce)

Protein AF-9

RefSeq ID

NM_004529

RefSeq Synonyms

NM_004529, NM_001286691, BC036089,

Research Areas

Cancer,Neurobiology,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Tumor Suppressors/Oncoproteins,Wnt Signaling

Research Areas (Faceted)

cancer,cell_biology,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

The human AF9 gene is one of the most common fusion partner genes with the MLL (mixed lineage leukemia) gene resulting in AF9/MLL translocations and leukemogenesis. AF9 is highly homologous to the gene product of ENL, another common MLL fusion partner gene. The function of AF9 is not known but through studies of ENL it is proposed to be a nuclear transactivating factor.

UniGene ID

Hs.591085

UniProt ID (eCommerce)

P42568

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.