human MLLT11 shRNA silencing AAV

Name
AAV-h-MLLT11-shRNA

Cat No
shAAV-215527

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MLLT11.

shAAV-215527

AAV-h-MLLT11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MLLT11 (myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AF1Q

Description (Vector)

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.

Gene ID

10962

Gene Name (Vector)

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

Gene Symbol

MLLT11

HGNC ID

HGNC:16997

ORF Size (aa)

273

RefSeq ID

NM_006818

RefSeq Synonyms

NM_006818, BC022448, BC021703, BC019253, BC009624, BC008445, BC006471,

Species

human

UniGene ID

Hs.75823

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.