human METAP1 shRNA silencing AAV

Name 
AAV-h-METAP1-shRNA
Cat No 
shAAV-215320
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human METAP1.

shAAV-215320
AAV-h-METAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human METAP1 (methionyl aminopeptidase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAP 1; MAP1A; metAP 1; MetAP1A; methionine aminopeptidase 1; peptidase M 1
Description (eCommerce)
Methionine aminopeptidase 1 (METAP1) cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). It is required for normal progression through the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P53582].
Gene ID
23173
Gene Name (eCommerce)
methionyl aminopeptidase 1
Gene Name (Vector)
methionyl aminopeptidase 1
Gene Symbol
METAP1
HGNC ID
HGNC:15789
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
819
ORF Size (bp)
819 bp
Protein Name (eCommerce)
Methionine aminopeptidase 1
RefSeq ID
NM_015143
RefSeq Synonyms
NM_015143, BC030054,
Research Areas
Neurobiology,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Methionine aminopeptidase 1 (METAP1) cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). It is required for normal progression through the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P53582].
UniGene ID
Hs.480364
UniProt ID (eCommerce)
P53582

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.