human MEP1B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MEP1B.
shAAV-215303
AAV-h-MEP1B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MEP1B (meprin A subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
Gene ID
4225
Gene Name (Vector)
meprin A subunit beta
Gene Symbol
MEP1B
HGNC ID
HGNC:7020
ORF Size (aa)
2106
ORF Size (bp)
2106 bp
RefSeq ID
NM_005925
RefSeq Synonyms
NM_005925, NM_001308171, BC144244, BC136559,
Species
human
UniGene ID
Hs.194777
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.