human MELK shRNA silencing AAV

Name
AAV-h-MELK-shRNA

Cat No
shAAV-215293

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MELK.

shAAV-215293

AAV-h-MELK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MELK (maternal embryonic leucine zipper kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hMELK; HPK38; maternal embryonic leucine zipper kinase; pEg3 kinase; protein kinase Eg3; protein kinase PK38; tyrosine-protein kinase MELK

Description (eCommerce)

Maternal embryonic leucine zipper kinase (MELK) phosphorylates ZNF622 and may contribute to its redirection to the nucleus. MELK may be involved in the inhibition of spliceosome assembly during mitosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q14680].

Gene ID

9833

Gene Name (eCommerce)

maternal embryonic leucine zipper kinase

Gene Name (Vector)

maternal embryonic leucine zipper kinase

Gene Symbol

MELK

HGNC ID

HGNC:16870

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1956

ORF Size (bp)

1956 bp

Protein Name (eCommerce)

Maternal embryonic leucine zipper kinase

RefSeq ID

NM_014791

RefSeq Synonyms

NM_014791, NM_001256693, NM_001256692, NM_001256691, NM_001256690, NM_001256689, NM_001256688, NM_001256687, NM_001256685, BC014039,

Research Areas

Apoptosis,Cell Cycle,Kinase/Phosphatase,Neurobiology,Neurodevelopment

Research Areas (Faceted)

cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction

Species

human

Target Sentence

Maternal embryonic leucine zipper kinase (MELK) phosphorylates ZNF622 and may contribute to its redirection to the nucleus. MELK may be involved in the inhibition of spliceosome assembly during mitosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q14680].

UniGene ID

Hs.184339

UniProt ID (eCommerce)

Q14680

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.