human MCOLN3 shRNA silencing AAV

Name
AAV-h-MCOLN3-shRNA

Cat No
shAAV-215200

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MCOLN3.

shAAV-215200

AAV-h-MCOLN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MCOLN3 (mucolipin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TRP-ML3; TRPML3

Description (Vector)

MCOLN3 encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

55283

Gene Name (Vector)

mucolipin 3

Gene Symbol

MCOLN3

HGNC ID

HGNC:13358

ORF Size (aa)

966

ORF Size (bp)

966 bp

RefSeq ID

NM_018298

RefSeq Synonyms

NM_018298, NM_001253693, BC060765,

Species

human

UniGene ID

Hs.535239

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.