human MBD5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MBD5.
shAAV-215095
AAV-h-MBD5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MBD5 (methyl-CpG binding domain protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MRD1
Description (Vector)
MBD5 encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
Gene ID
55777
Gene Name (Vector)
methyl-CpG binding domain protein 5
Gene Symbol
MBD5
HGNC ID
HGNC:20444
ORF Size (aa)
4485
ORF Size (bp)
4485 bp
RefSeq ID
NM_018328
RefSeq Synonyms
NM_018328, BC150264, BC014534,
Species
human
UniGene ID
Hs.458312
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.