human MARK4 shRNA silencing AAV

Name
AAV-h-MARK4-shRNA

Cat No
shAAV-215039

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MARK4.

shAAV-215039

AAV-h-MARK4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MARK4 (microtubule affinity regulating kinase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D

Description (Vector)

MARK4 encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

57787

Gene Name (Vector)

microtubule affinity regulating kinase 4

Gene Symbol

MARK4

HGNC ID

HGNC:13538

ORF Size (aa)

2067

ORF Size (bp)

2067 bp

RefSeq ID

NM_031417

RefSeq Synonyms

NM_031417, NM_001199867, BC166620, BC071948, BC009049,

Species

human

UniGene ID

Hs.34314

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.