human MARK3 shRNA silencing AAV

Name
AAV-h-MARK3-shRNA

Cat No
shAAV-215038

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MARK3.

shAAV-215038

AAV-h-MARK3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MARK3 (microtubule affinity regulating kinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cdc25C-associated protein kinase 1; CTAK1; C-TAK1; ELKL motif kinase 2; EMK-2; KP78; MAP/microtubule affinity-regulating kinase 3; PAR1A; Par-1a; protein kinase STK10; ser/Thr protein kinase PAR-1; serine/threonine-protein kinase p78

Description (eCommerce)

MARK3 (Microtubule-affinity regulating kinase 3) is also known as PAR-1a (partition-defective 1a) and is a member of a family of kinases that plays a role in cell polarity and cell-cycle control. There are four PAR-1/MARK isoforms encoded by independent genes: MARK1 (PAR-1c), MARK2 (PAR-1b/EMK), MARK3(PAR-1a), and MARK4 (PAR-1d/MARKL1). MARK isoforms phosphorylates microtubule associated proteins (MAPs) such as MAP2, MAP4, and tau to regulate their association with microtubules.

Description (Vector)

MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

4140

Gene Name (eCommerce)

microtubule affinity regulating kinase 3

Gene Name (Vector)

microtubule affinity regulating kinase 3

Gene Symbol

MARK3

HGNC ID

HGNC:6897

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2190

ORF Size (bp)

2190 bp

Protein Name (eCommerce)

MAP/microtubule affinity-regulating kinase 3

RefSeq ID

NM_002376

RefSeq Synonyms

NM_002376, NM_001128921, NM_001128920, NM_001128919, NM_001128918, BC024773,

Research Areas

Kinase/Phosphatase,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology

Species

human

Target Sentence

MARK3 (Microtubule-affinity regulating kinase 3) is also known as PAR-1a (partition-defective 1a) and is a member of a family of kinases that plays a role in cell polarity and cell-cycle control. There are four PAR-1/MARK isoforms encoded by independent genes: MARK1 (PAR-1c), MARK2 (PAR-1b/EMK), MARK3(PAR-1a), and MARK4 (PAR-1d/MARKL1). MARK isoforms phosphorylates microtubule associated proteins (MAPs) such as MAP2, MAP4, and tau to regulate their association with microtubules.

UniGene ID

Hs.35828

UniProt ID (eCommerce)

P27448

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.