human MARCH8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MARCH8.
shAAV-215027
AAV-h-MARCH8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MARCH8 (membrane associated ring-CH-type finger 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
c-MIR; CMIR; MARCH-VIII; MIR; RNF178
Description (Vector)
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 (PubMed 12582153); Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)
Gene ID
220972
Gene Name (Vector)
membrane associated ring-CH-type finger 8
Gene Symbol
8-Mar
HGNC ID
HGNC:23356
ORF Size (aa)
876
ORF Size (bp)
876 bp
RefSeq ID
NM_145021
RefSeq Synonyms
NM_145021, NM_001282866, NM_001002266, NM_001002265, BC066988, BC025394,
Species
human
UniGene ID
Hs.499489
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.