human MAP7 shRNA silencing AAV

Name 
AAV-h-MAP7-shRNA
Cat No 
shAAV-214958
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MAP7.

shAAV-214958
AAV-h-MAP7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAP7 (microtubule associated protein 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115)); EMAP115; E-MAP-115; ensconsin; epithelial microtubule-associated protein of 115 kDa; MAP-7; Microtubule-associated protein 7
Description (eCommerce)
MAP7 was first identified in HeLa cells as E-MAP-115. It is predominantly expressed in cells of epithelial origin and proposed to function as a stabilizer of microtubules important for regulating cell polarization. Disruption of the MAP7 gene has been associated with cases of sacral dysgenesis; however MAP7 knockout mice do not display the associated phenotype. In mice it has been shown to be important to sperm cell development.
Description (Vector)
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
9053
Gene Name (eCommerce)
microtubule associated protein 7
Gene Name (Vector)
microtubule associated protein 7
Gene Symbol
MAP7
HGNC ID
HGNC:6869
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2250
ORF Size (bp)
2250 bp
Protein Name (eCommerce)
Ensconsin
RefSeq ID
NM_003980
RefSeq Synonyms
NM_003980, NM_001198619, NM_001198618, NM_001198617, NM_001198616, NM_001198615, NM_001198614, NM_001198611, NM_001198609, NM_001198608, BC025777,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
MAP7 was first identified in HeLa cells as E-MAP-115. It is predominantly expressed in cells of epithelial origin and proposed to function as a stabilizer of microtubules important for regulating cell polarization. Disruption of the MAP7 gene has been associated with cases of sacral dysgenesis; however MAP7 knockout mice do not display the associated phenotype. In mice it has been shown to be important to sperm cell development.
UniGene ID
Hs.486548
UniProt ID (eCommerce)
Q14244

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.