human MAML3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAML3.
shAAV-214870
AAV-h-MAML3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAML3 (mastermind like transcriptional coactivator 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAG repeat containing (glia-derived nexin I alpha); CAGH3; ERDA3; expanded repeat domain, CAG/CTG 3; GDN; MAM2; MAM-2; mam-3; mastermind-like protein 3; polyglutamine rich; TNRC3; trinucleotide repeat containing 3
Description (eCommerce)
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML3 is a coactivator for NOTCH signaling. MAML3 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors.
Gene ID
55534
Gene Name (eCommerce)
mastermind like transcriptional coactivator 3
Gene Name (Vector)
mastermind like transcriptional coactivator 3
Gene Symbol
MAML3
HGNC ID
HGNC:16272
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3402
ORF Size (bp)
3402 bp
Protein Name (eCommerce)
Mastermind-like protein 3
RefSeq ID
NM_018717
RefSeq Synonyms
NM_018717, BC137131, BC137130,
Research Areas
Cancer,Gene Expression,Notch Signaling,Nuclear Receptor Coactivators,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML3 is a coactivator for NOTCH signaling. MAML3 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors.
UniGene ID
Hs.586165
UniProt ID (eCommerce)
Q96JK9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.