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human MAGEL2 shRNA silencing AAV

Name 
AAV-h-MAGEL2-shRNA
Cat No 
shAAV-214846
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MAGEL2.

shAAV-214846
AAV-h-MAGEL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAGEL2 (MAGE family member L2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NDNL1; nM15; PWLS; SHFYNG
Description (Vector)
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
Gene ID
54551
Gene Name (Vector)
MAGE family member L2
Gene Symbol
MAGEL2
HGNC ID
HGNC:6814
ORF Size (aa)
1941
ORF Size (bp)
1941 bp
RefSeq ID
NM_019066
RefSeq Synonyms
NM_019066, BC167825,
Species
human
UniGene ID
Hs.141496

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.