human MAFB shRNA silencing AAV

Name 
AAV-h-MAFB-shRNA
Cat No 
shAAV-214793
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MAFB.

shAAV-214793
AAV-h-MAFB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAFB (MAF bZIP transcription factor B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DURS3; Kreisler maf-related leucine zipper homolog; KRML; Maf-B; MAFB/Kreisler basic region/leucine zipper transcription factor; MCTO; transcription factor MafB; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
Description (eCommerce)
MafB is a member of the Maf basic leucine-zipper containing transcription factor family. MafB is an islet-enriched protein that plays a role in beta cell-specific and glucose-responsive insulin gene transcription. MafB is expressed in all developing insulin and glucagon producing cells but is restricted to alpha cells in adults. MafB is has been shown to be critical for alpha and beta cell differentiation. Alternative names for MafB include v-maf musculoaponeurotic fibrosarcoma oncogene homolog B, transcription factor Maf1, segmentation protein KR, kreisler, Krml, Krml1, kr, and Maf1.
Description (Vector)
MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
Gene ID
9935
Gene Name (eCommerce)
MAF bZIP transcription factor B
Gene Name (Vector)
MAF bZIP transcription factor B
Gene Symbol
MAFB
HGNC ID
HGNC:6408
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
972
ORF Size (bp)
972 bp
Protein Name (eCommerce)
Transcription factor MafB
RefSeq ID
NM_005461
RefSeq Synonyms
NM_005461, BC036689, BC028098,
Research Areas
Neurobiology,Neurodevelopment
Research Areas (Faceted)
neurobiology,developmental_biology
Species
human
Target Sentence
MafB is a member of the Maf basic leucine-zipper containing transcription factor family. MafB is an islet-enriched protein that plays a role in beta cell-specific and glucose-responsive insulin gene transcription. MafB is expressed in all developing insulin and glucagon producing cells but is restricted to alpha cells in adults. MafB is has been shown to be critical for alpha and beta cell differentiation. Alternative names for MafB include v-maf musculoaponeurotic fibrosarcoma oncogene homolog B, transcription factor Maf1, segmentation protein KR, kreisler, Krml, Krml1, kr, and Maf1.
UniGene ID
Hs.169487
UniProt ID (eCommerce)
Q9Y5Q3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.