human LZTS1 shRNA silencing AAV

Name 
AAV-h-LZTS1-shRNA
Cat No 
shAAV-214757
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LZTS1.

shAAV-214757
AAV-h-LZTS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LZTS1 (leucine zipper tumor suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
F37; F37/Esophageal cancer-related gene-coding leucine-zipper motif; FEZ1; leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1
Description (eCommerce)
Leucine zipper putative tumor suppressor 1 (LZTS1) is a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. LZTS1 may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex [taken from NCBI Entrez Gene (Gene ID: 11178)].
Description (Vector)
LZTS1 encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. LZTS1 is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
Gene ID
11178
Gene Name (eCommerce)
leucine zipper tumor suppressor 1
Gene Name (Vector)
leucine zipper tumor suppressor 1
Gene Symbol
LZTS1
HGNC ID
HGNC:13861
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1791
ORF Size (bp)
1791 bp
Protein Name (eCommerce)
Leucine zipper putative tumor suppressor 1
RefSeq ID
NM_021020
RefSeq Synonyms
NM_021020, BC075007, BC075006,
Research Areas
Autophagy,Cancer,Cell Cycle,Gene Expression,Golgi Apparatus,Neurobiology,Synapse,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
Leucine zipper putative tumor suppressor 1 (LZTS1) is a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. LZTS1 may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex [taken from NCBI Entrez Gene (Gene ID: 11178)].
UniGene ID
Hs.521432
UniProt ID (eCommerce)
Q9Y250

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.