human LTBP1 shRNA silencing AAV

Name
AAV-h-LTBP1-shRNA

Cat No
shAAV-214663

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human LTBP1.

shAAV-214663

AAV-h-LTBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LTBP1 (latent transforming growth factor beta binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

LTBP1 belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

4052

Gene Name (Vector)

latent transforming growth factor beta binding protein 1

Gene Symbol

LTBP1

HGNC ID

HGNC:6714

ORF Size (aa)

4062

ORF Size (bp)

4062 bp

RefSeq ID

NM_000627

RefSeq Synonyms

NM_206943, NM_001166266, NM_001166265, NM_001166264, NM_000627, BC144128, BC130289,

Species

human

UniGene ID

Hs.713533

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.