human LRRK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LRRK2.
shAAV-214603
AAV-h-LRRK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LRRK2 (leucine rich repeat kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Description (Vector)
LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Gene ID
120892
Gene Name (Vector)
leucine rich repeat kinase 2
Gene Symbol
LRRK2
HGNC ID
HGNC:18618
ORF Size (aa)
7584
ORF Size (bp)
7584 bp
RefSeq ID
NM_198578
RefSeq Synonyms
NM_198578, BC117180,
Species
human
UniGene ID
Hs.187636
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.