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human LRRC16A shRNA silencing AAV

Name 
AAV-h-LRRC16A-shRNA
Cat No 
shAAV-214522
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CARMIL1.

shAAV-214522
AAV-h-LRRC16A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CARMIL1 (capping protein regulator and myosin 1 linker 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
capping protein regulator and myosin 1 linker protein 1; capping protein, Arp2/3 and myosin-I linker homolog 1; capping protein, Arp2/3 and myosin-I linker protein 1; capping protein, Arp2/3, and Myosin-I Linker homolog 1; CARMIL; CARMIL homolog; CARMIL1a; dJ501N12.1; dJ501N12.5; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; leucine-rich repeat-containing protein 16A; LRRC16; LRRC16A; testicular tissue protein Li 107
Description (eCommerce)
CARMIL binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. It increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. CARMIL Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity).CARMIL may control actin dynamics in lamellipodi and be required for cell migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5VZK9].
Gene ID
55604
Gene Name (eCommerce)
capping protein regulator and myosin 1 linker 1
Gene Name (Vector)
capping protein regulator and myosin 1 linker 1
Gene Symbol
CARMIL1
HGNC ID
HGNC:21581
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4098
ORF Size (bp)
4098 bp
Protein Name (eCommerce)
F-actin-uncapping protein LRRC16A
RefSeq ID
NM_017640
RefSeq Synonyms
NM_017640, NM_001173977, BC172573, BC172272, BC140770,
Research Areas
Cell Biology,Metabolism/Metabolic Process,Ubiquitination
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
CARMIL binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. It increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. CARMIL Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity).CARMIL may control actin dynamics in lamellipodi and be required for cell migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5VZK9].
UniGene ID
Hs.670507
UniProt ID (eCommerce)
Q5VZK9

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.