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human LPIN2 shRNA silencing AAV

Name 
AAV-h-LPIN2-shRNA
Cat No 
shAAV-214457
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LPIN2.

shAAV-214457
AAV-h-LPIN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LPIN2 (lipin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Lipin-2; phosphatidate phosphatase LPIN2
Description (eCommerce)
Lipin 2 plays important roles in controlling the metabolism of fatty acids at differents levels. It acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Lipin 2 also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q92539].
Description (Vector)
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
Gene ID
9663
Gene Name (eCommerce)
lipin 2
Gene Name (Vector)
lipin 2
Gene Symbol
LPIN2
HGNC ID
HGNC:14450
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2691
ORF Size (bp)
2691 bp
Protein Name (eCommerce)
Phosphatidate phosphatase LPIN2
RefSeq ID
NM_014646
RefSeq Synonyms
NM_014646, BC160018, BC152448,
Research Areas
Metabolism/Metabolic Process,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Lipin 2 plays important roles in controlling the metabolism of fatty acids at differents levels. It acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Lipin 2 also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q92539].
UniGene ID
Hs.132342
UniProt ID (eCommerce)
Q92539

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.