human LOXL1 shRNA silencing AAV

Name
AAV-h-LOXL1-shRNA

Cat No
shAAV-214436

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human LOXL1.

shAAV-214436

AAV-h-LOXL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LOXL1 (lysyl oxidase like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LOL; LOXL

Description (Vector)

LOXL1 encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene ID

4016

Gene Name (Vector)

lysyl oxidase like 1

Gene Symbol

LOXL1

HGNC ID

HGNC:6665

ORF Size (aa)

1725

ORF Size (bp)

1725 bp

RefSeq ID

NM_005576

RefSeq Synonyms

NM_005576, BC068542, BC015090,

Species

human

UniGene ID

Hs.65436

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.