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human LOXHD1 shRNA silencing AAV

Name 
AAV-h-LOXHD1-shRNA
Cat No 
shAAV-214435
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LOXHD1.

shAAV-214435
AAV-h-LOXHD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LOXHD1 (lipoxygenase homology domains 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DFNB77; LH2D1
Description (Vector)
LOXHD1 encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory hair cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
125336
Gene Name (Vector)
lipoxygenase homology domains 1
Gene Symbol
LOXHD1
HGNC ID
HGNC:26521
ORF Size (aa)
3345
ORF Size (bp)
3345 bp
RefSeq ID
NM_144612
RefSeq Synonyms
NM_144612, NM_001308013, NM_001173129, NM_001145473, NM_001145472, BC041860,
Species
human
UniGene ID
Hs.345877

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.