human LOX shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LOX.
shAAV-214432
AAV-h-LOX-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LOX (lysyl oxidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AAT10
Description (Vector)
LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4015
Gene Name (Vector)
lysyl oxidase
Gene Symbol
LOX
HGNC ID
HGNC:6664
ORF Size (aa)
1254
ORF Size (bp)
1254 bp
RefSeq ID
NM_002317
RefSeq Synonyms
NM_002317, NM_001317073, NM_001178102, BC089436, BC074872, BC074820,
Species
human
UniGene ID
Hs.102267
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.