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human LONP1 shRNA silencing AAV

Name 
AAV-h-LONP1-shRNA
Cat No 
shAAV-214419
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LONP1.

shAAV-214419
AAV-h-LONP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LONP1 (lon peptidase 1, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CODASS; hLON; hLON ATP-dependent protease; LON; lon protease homolog, mitochondrial; lon protease-like protein; LonHS; LONP; mitochondrial ATP-dependent protease Lon; mitochondrial lon protease-like protein; PIM1; PRSS15; serine protease 15
Description (eCommerce)
LONP1 is an ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P36776].
Description (Vector)
LONP1 encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.
Gene ID
9361
Gene Name (eCommerce)
lon peptidase 1, mitochondrial
Gene Name (Vector)
lon peptidase 1, mitochondrial
Gene Symbol
LONP1
HGNC ID
HGNC:9479
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2880
ORF Size (bp)
2880 bp
Protein Name (eCommerce)
Lon protease homolog, mitochondrial
RefSeq ID
NM_004793
RefSeq Synonyms
NM_004793, NM_001276480, NM_001276479, BC000235,
Research Areas
Hypoxia,Mitochondrion,RNA Binding
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
LONP1 is an ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P36776].
UniGene ID
Hs.350265
UniProt ID (eCommerce)
P36776

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.