human GPBP1 shRNA silencing AAV

Name
AAV-h-GPBP1-shRNA

Cat No
shAAV-214251

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GPBP1.

shAAV-214251

AAV-h-GPBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPBP1 (GC-rich promoter binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GPBP; SSH6; VASCULIN

Description (Vector)

GPBP1 was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

65056

Gene Name (Vector)

GC-rich promoter binding protein 1

Gene Symbol

GPBP1

HGNC ID

HGNC:29520

ORF Size (aa)

1422

ORF Size (bp)

1422 bp

RefSeq ID

NM_022913

RefSeq Synonyms

NM_022913, NM_001331037, NM_001203246, NM_001127236, NM_001127235, BC113004, BC000267,

Species

human

UniGene ID

Hs.444279

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.