human PBX1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PBX1.
shAAV-214146
AAV-h-PBX1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PBX1 (PBX homeobox 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5087
Gene Name (Vector)
PBX homeobox 1
Gene Symbol
PBX1
HGNC ID
HGNC:8632
ORF Size (aa)
1293
ORF Size (bp)
1293 bp
RefSeq ID
NM_002585
RefSeq Synonyms
NM_002585, NM_001204963, NM_001204961, BC101578,
Species
human
UniGene ID
Hs.557097
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.