human LMTK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LMTK2.
shAAV-214049
AAV-h-LMTK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LMTK2 (lemur tyrosine kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AATYK2; apoptosis-associated tyrosine kinase 2; brain-enriched kinase; BREK; CDK5/p35-regulated kinase; cprk; cyclin-dependent kinase 5/p35-regulated kinase; hBREK; kinase/phosphatase/inhibitor 2; KPI2; KPI-2; Lemur tyrosine kinase 2; LMR2; PPP1R100; protein phosphatase 1, regulatory subunit 100; serine/threonine-protein kinase KPI-2; serine/threonine-protein kinase LMTK2
Description (eCommerce)
Lemur tyrosine kinase (LMTK2) belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. LMTK2 interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. LMTK2 is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggest an essential role of this protein in spermatogeness [taken from NCBI Entrez Gene (Gene ID: 22853)].
Description (Vector)
LMTK2 belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
Gene ID
22853
Gene Name (eCommerce)
lemur tyrosine kinase 2
Gene Name (Vector)
lemur tyrosine kinase 2
Gene Symbol
LMTK2
HGNC ID
HGNC:17880
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4512
ORF Size (bp)
4512 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase LMTK2
RefSeq ID
NM_014916
RefSeq Synonyms
NM_014916, BC167828,
Research Areas
Golgi Apparatus,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Lemur tyrosine kinase (LMTK2) belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. LMTK2 interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. LMTK2 is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggest an essential role of this protein in spermatogeness [taken from NCBI Entrez Gene (Gene ID: 22853)].
UniGene ID
Hs.444179
UniProt ID (eCommerce)
Q8IWU2
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.