human LMBR1 shRNA silencing AAV

Cat. No: shAAV-214011

Availability: 4-5 weeks

Name: AAV-h-LMBR1-shRNA

This is an AAV expressing shRNA for silencing of Human LMBR1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LMBR1
Gene Name: limb development membrane protein 1
Gene ID: 64327
Gene Synonyms: ACHP; C7orf2; DIF14; LSS; PPD2; THYP; TPT; ZRS
ORF Size: 1473 bp
RefSeq#: NM_022458
Gene Description: LMBR1 encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.
UniGene ID: Hs.209989
HGNC ID: HGNC:13243