human LITAF shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LITAF.
shAAV-213987
AAV-h-LITAF-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LITAF (lipopolysaccharide induced TNF factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PIG7; SIMPLE; TP53I7
Description (Vector)
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Gene ID
9516
Gene Name (Vector)
lipopolysaccharide induced TNF factor
Gene Symbol
LITAF
HGNC ID
HGNC:16841
ORF Size (aa)
486
RefSeq ID
NM_004862
RefSeq Synonyms
NM_004862, NM_001136473, NM_001136472, BC101969, BC101402, BC101401, BC096066, BC096065, BC096063, BC046154, BC039840, BC016491, BC008309, BC000053,
Species
human
UniGene ID
Hs.459940
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.