human LGALS3 shRNA silencing AAV

Name
AAV-h-LGALS3-shRNA

Cat No
shAAV-213851

Availability
Immediate

This is an AAV expressing shRNA for silencing of Human LGALS3.

shAAV-213851

AAV-h-LGALS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LGALS3 (galectin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2

Description (Vector)

LGALS3 encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.

Gene ID

3958

Gene Name (Vector)

galectin 3

Gene Symbol

LGALS3

HGNC ID

HGNC:6563

ORF Size (aa)

753

RefSeq ID

NM_002306

RefSeq Synonyms

NM_002306, NM_001177388, BC068068, BC053667, BC001120,

Species

human

UniGene ID

Hs.531081

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.