human LEPR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LEPR.
shAAV-213834
AAV-h-LEPR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LEPR (leptin receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD295; LEP-R; LEPRD; OB-R; OBR
Description (Vector)
LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Gene ID
3953
Gene Name (Vector)
leptin receptor
Gene Symbol
LEPR
HGNC ID
HGNC:6554
ORF Size (aa)
3498
ORF Size (bp)
3498 bp
RefSeq ID
NM_002303
RefSeq Synonyms
NM_002303, NM_001198689, NM_001198688, NM_001198687, NM_001003680, NM_001003679, BC160009,
Species
human
UniGene ID
Hs.705413
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.