human LEO1 shRNA silencing AAV

Name 
AAV-h-LEO1-shRNA
Cat No 
shAAV-213829
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LEO1.

shAAV-213829
AAV-h-LEO1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Leo1 Paf1/RNA polymerase II complex component; Leo1, Paf1/RNA polymerase II complex component, homolog; RDL; replicative senescence down-regulated leo1-like protein; RNA polymerase-associated protein LEO1
Description (eCommerce)
Leo1 is a component of the Paf/RNA polymerase II complex which consists of at least Leo1, CDC73, PAF1, and CTR9. The PAF1/RNA polymerase II complex plays a role in transcriptional initiation and elongation, histone methylation, and RNA processing.
Description (Vector)
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 (PubMed 15632063)).(supplied by OMIM, Mar 2008)
Gene ID
123169
Gene Name (eCommerce)
LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Name (Vector)
LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Symbol
LEO1
HGNC ID
HGNC:30401
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2001
ORF Size (bp)
2001 bp
Protein Name (eCommerce)
RNA polymerase-associated protein LEO1
RefSeq ID
NM_138792
RefSeq Synonyms
NM_138792, NM_001323904, NM_001323903, NM_001286430, BC018147,
Research Areas
Histone Modification,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Leo1 is a component of the Paf/RNA polymerase II complex which consists of at least Leo1, CDC73, PAF1, and CTR9. The PAF1/RNA polymerase II complex plays a role in transcriptional initiation and elongation, histone methylation, and RNA processing.
UniGene ID
Hs.567662
UniProt ID (eCommerce)
Q8WVC0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.