human LECT1 shRNA silencing AAV

Name
AAV-h-LECT1-shRNA

Cat No
shAAV-213809

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CNMD.

shAAV-213809

AAV-h-LECT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CNMD (chondromodulin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BRICD3; CHM-I; CHM1; LECT1; MYETS1

Description (Vector)

LECT1 encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. LECT1 is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

11061

Gene Name (Vector)

chondromodulin

Gene Symbol

CNMD

HGNC ID

HGNC:17005

ORF Size (aa)

1002

ORF Size (bp)

1002 bp

RefSeq ID

NM_007015

RefSeq Synonyms

NM_007015, NM_001011705, BC025659,

Species

human

UniGene ID

Hs.421391

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.