human LDB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LDB2.
shAAV-213783
AAV-h-LDB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LDB2 (LIM domain binding 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLIM1; LDB-2; LDB1
Description (Vector)
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 (PubMed 9799849)). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 (PubMed 9315627)). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 (PubMed 9192866)) and Clim2/Lbd1/Nli (Agulnick et al., 1996 (PubMed 8918878); Jurata et al., 1996 (PubMed 8876198); Bach et al., 1997 (PubMed 9192866)) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.(supplied by OMIM, Jul 2010)
Gene ID
9079
Gene Name (Vector)
LIM domain binding 2
Gene Symbol
LDB2
HGNC ID
HGNC:6533
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
RefSeq ID
NM_001290
RefSeq Synonyms
NM_001304435, NM_001304434, NM_001290, NM_001130834, BC034019,
Species
human
UniGene ID
Hs.714330
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.