human LARS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LARS.
shAAV-213686
AAV-h-LARS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LARS (leucyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; hr025Cl; HSPC192; ILFS1; LARS1; leucine translase; leucine tRNA ligase 1, cytoplasmic; leucine--tRNA ligase, cytoplasmic; Leucyl-tRNA synthetase; LEURS; LEUS; LFIS; LRS; PIG44; proliferation-inducing gene 44; RNTLS
Description (eCommerce)
Leucyl-tRNA synthetase (LARS) catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. LARS exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P2J5].
Description (Vector)
LARS encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
Gene ID
51520
Gene Name (eCommerce)
leucyl-tRNA synthetase
Gene Name (Vector)
leucyl-tRNA synthetase
Gene Symbol
LARS
HGNC ID
HGNC:6512
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3531
ORF Size (bp)
3531 bp
Protein Name (eCommerce)
Leucine--tRNA ligase, cytoplasmic
RefSeq ID
NM_020117
RefSeq Synonyms
NM_020117, NM_016460, NM_001317965, NM_001317964, BC152422, BC151214, BC150213,
Research Areas
Gene Expression,Metabolism/Metabolic Process,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Leucyl-tRNA synthetase (LARS) catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. LARS exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P2J5].
UniGene ID
Hs.432674
UniProt ID (eCommerce)
Q9P2J5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.