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human LARGE shRNA silencing AAV

Name 
AAV-h-LARGE-shRNA
Cat No 
shAAV-213675
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LARGE1.

shAAV-213675
AAV-h-LARGE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LARGE; MDC1D; MDDGA6; MDDGB6
Description (Vector)
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Gene ID
9215
Gene Name (Vector)
LARGE xylosyl- and glucuronyltransferase 1
Gene Symbol
LARGE1
HGNC ID
HGNC:6511
ORF Size (aa)
2271
ORF Size (bp)
2271 bp
RefSeq ID
NM_004737
RefSeq Synonyms
NM_133642, NM_004737, BC126404, BC117425,
Species
human
UniGene ID
Hs.474667

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.