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human LAMA3 shRNA silencing AAV

Name 
AAV-h-LAMA3-shRNA
Cat No 
shAAV-213648
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LAMA3.

shAAV-213648
AAV-h-LAMA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LAMA3 (laminin subunit alpha 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BM600; E170; LAMNA; LOCS
Description (Vector)
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene ID
3909
Gene Name (Vector)
laminin subunit alpha 3
Gene Symbol
LAMA3
HGNC ID
HGNC:6483
ORF Size (aa)
5175
ORF Size (bp)
5175 bp
RefSeq ID
NM_000227
RefSeq Synonyms
NM_198129, NM_001302996, NM_001127718, NM_001127717, NM_000227, BC172580, BC172402,
Species
human
UniGene ID
Hs.436367

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.