human L3MBTL2 shRNA silencing AAV

Name
AAV-h-L3MBTL2-shRNA

Cat No
shAAV-213626

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human L3MBTL2.

shAAV-213626

AAV-h-L3MBTL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human L3MBTL2 (L3MBTL2 polycomb repressive complex 1 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

70

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

H-l(3)mbt-l; H-l(3)mbt-like protein 2; l(3)mbt-like 2; L(3)mbt-like protein 2; L3MBT; lethal(3)malignant brain tumor-like protein 2

Description (eCommerce)

Lethal (3) malignant brain tumor-like protein 2 (L3MBTL2) is a putative polycomb group (PcG) protein. Its association with a chromatin-remodeling complex suggests that it may contribute to the repression of genes that trigger the cell into mitosis. L3MBTL2 binds to monomethylated and dimethylated 'Lys-20' on histone H4. It also binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q969R5].

Gene ID

83746

Gene Name (eCommerce)

L3MBTL2, polycomb repressive complex 1 subunit

Gene Name (Vector)

L3MBTL2 polycomb repressive complex 1 subunit

Gene Symbol

L3MBTL2

HGNC ID

HGNC:18594

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2118

ORF Size (bp)

2118 bp

Protein Name (eCommerce)

Lethal(3)malignant brain tumor-like protein 2

RefSeq ID

NM_031488

RefSeq Synonyms

NM_031488, BC017191,

Research Areas

Chromatin Remodeling,Histone Modification,Transcription Factor/Regulator,Zinc-finger

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

Lethal (3) malignant brain tumor-like protein 2 (L3MBTL2) is a putative polycomb group (PcG) protein. Its association with a chromatin-remodeling complex suggests that it may contribute to the repression of genes that trigger the cell into mitosis. L3MBTL2 binds to monomethylated and dimethylated 'Lys-20' on histone H4. It also binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q969R5].

UniGene ID

Hs.517641

UniProt ID (eCommerce)

Q969R5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.