human KYNU shRNA silencing AAV

Name
AAV-h-KYNU-shRNA

Cat No
shAAV-213620

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human KYNU.

shAAV-213620

AAV-h-KYNU-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KYNU (kynureninase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

KYNUU

Description (Vector)

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.

Gene ID

8942

Gene Name (Vector)

kynureninase

Gene Symbol

KYNU

HGNC ID

HGNC:6469

ORF Size (aa)

924

ORF Size (bp)

924 bp

RefSeq ID

NM_003937

RefSeq Synonyms

NM_003937, NM_001199241, NM_001032998, BC000879,

Species

human

UniGene ID

Hs.470126

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.