human KLRC3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KLRC3.
shAAV-213323
AAV-h-KLRC3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KLRC3 (killer cell lectin like receptor C3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NKG2-E; NKG2E
Description (Vector)
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
3823
Gene Name (Vector)
killer cell lectin like receptor C3
Gene Symbol
KLRC3
HGNC ID
HGNC:6376
ORF Size (aa)
774
RefSeq ID
NM_002261
RefSeq Synonyms
NM_007333, NM_002261, BC160065,
Species
human
UniGene ID
Hs.654362
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.