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human KLHL4 shRNA silencing AAV

Name 
AAV-h-KLHL4-shRNA
Cat No 
shAAV-213263
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KLHL4.

shAAV-213263
AAV-h-KLHL4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KLHL4 (kelch like family member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DKELCHL; kelch-like protein 4; KHL4
Description (eCommerce)
Stromal membrane-associated protein 2 (SMAP2) is a GTPase activating protein that acts on ARF1. SMAP2 Can also activate ARF6 (in vitro) It may play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WU79].
Description (Vector)
KLHL4 encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
56062
Gene Name (eCommerce)
kelch like family member 4
Gene Name (Vector)
kelch like family member 4
Gene Symbol
KLHL4
HGNC ID
HGNC:6355
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2163
ORF Size (bp)
2163 bp
Protein Name (eCommerce)
Kelch-like protein 4
RefSeq ID
NM_019117
RefSeq Synonyms
NM_057162, NM_019117, BC161675, BC146677, BC142652, BC140840, BC140839,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Stromal membrane-associated protein 2 (SMAP2) is a GTPase activating protein that acts on ARF1. SMAP2 Can also activate ARF6 (in vitro) It may play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WU79].
UniGene ID
Hs.49075
UniProt ID (eCommerce)
Q9C0H6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.