human KIFAP3 shRNA silencing AAV

Name
AAV-h-KIFAP3-shRNA

Cat No
shAAV-213118

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KIFAP3.

shAAV-213118

AAV-h-KIFAP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KIFAP3 (kinesin associated protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP; Smg-GDS

Description (Vector)

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

22920

Gene Name (Vector)

kinesin associated protein 3

Gene Symbol

KIFAP3

HGNC ID

HGNC:17060

ORF Size (aa)

2379

ORF Size (bp)

2379 bp

RefSeq ID

NM_014970

RefSeq Synonyms

NM_014970, NM_001204517, NM_001204516, NM_001204514, BC028679,

Species

human

UniGene ID

Hs.433442

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.